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Rheumatoid Arthritis: Cause

Description: A chronic, disabling condition, rheumatoid arthritis (RA) can cause joint pain and deformity. Characterized by chronic inflammation, experts believe that an autoimmune disorder causes RA. It strikes during productive adult years, between the ages of 20 and 65, with median onset at age 50. This course explores the pathophysiology and the role of the immune system in rheumatoid arthritis.

COURSE OUTLINE

INTRODUCTION
1. Course Information
2. Interface Tour
3. Course Overview

PATHOPHYSIOLOGY
4. Objectives
5. Risk Factors: Genetic
6. Risk Factors: Infectious Agents
7. Risk Factors: Hormonal
8. The Synovial Joint
9. The Immune System
10. Pathogenesis: Immune Factors
11. Pathogenesis: Cytokines, Chemokines
12. Pathogenesis: ROS, RNS
13. Pathogenesis: Angiogenesis
14. Progress Check

EPIDEMIOLOGY
15. Objectives
16. Prevalence
17. Incidence and Economic Impact
18. Progress Check

CONCLUSION
19. Summary

COURSE OBJECTIVES

Students completing this course should be able to:

Describe rheumatoid arthritis risk factors
Describe the major synovium cell types and their functions
Distinguish between normal and rheumatoid joint structure and function
Explain rheumatoid arthritis pathogenic mechanism
Describe rheumatoid arthritis prevalence and incidence in different geographic regions
Explain how age and gender impact prevalence rates
Explain the rheumatoid arthritis risk factors, including factors that increase severity
Describe RA's socioeconomic effects

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