SeerPharma Pty Ltd :: DISCover web-based training

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Immunity and Disease

Description: This course describes the role of the immune system in human disease. It covers the structure and function of the immune system, and details how the immune system can be up-regulated for vaccination against infectious agents, and down-regulated to treat autoimmune diseases. The generation of monoclonal antibodies and their therapeutic use is also described.

COURSE OUTLINE

INTRODUCTION
1. Course Information
2. Interface Tour
3. Course Overview

BACKGROUND
4. Objectives
5. Immunity and Disease
6. Immune Response
7. Mechanism
8. Re-engineering
9. Progress Check

UP REGULATION
10. Objectives
11. Vaccines
12. Vaccine Examples
13. Influenza
14. Progress Check

DOWN REGULATION
13. Objectives
14. Autoimmune Diseases
15. Tolerance
16. MHC-Blocking Peptides
17. Other Immune Targets
18. Progress Check

IMMUNOTHERAPY
19. Objectives
20. Monoclonal Antibodies
21. Human Antibodies
22. Antibody Therapeutics
23. Progress Check

COURSE OBJECTIVES

Students completing this course should be able to:

List the cells and proteins involved in eliciting an immune response
Specify the four disease groups that have an immune component involved in their pathology
Understand the different mechanisms by which the immune response responds to and eradicates infectious agents from the body
Explain how the immune system can be manipulated
Define the different ways in which the immune system can be activated or upregulated
Understand the history of vaccine development
Explain why polymorphic viruses like influenza provide a special challenge to vaccine development
List the target organs of many autoimmune diseases
Describe the concept of tolerance
Understand how MHC molecules can be blocked using peptides
Give several examples of proteins that are targets for immune modulation
Describe how monoclonal antibodies are generated
Explain how mouse antibodies can be "humanized" for use as therapeutics
Give two examples of how monoclonal antibodies are used as therapeutic agent

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