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Depression (MDD): Cause

Description: The diagnosis for depression is termed Major Depressive Disorder (MDD) and is one of the most prevalent mental illnesses, affecting an estimated 17% of the world population at some point in their lifetime. A heterogeneous and complicated mood disorder, depression can wreak havoc on an individual and, in the most tragic cases, can culminate in suicide. This course reviews the theories of pathology for depression.

COURSE OUTLINE

INTRODUCTION
1. Course Information
2. Interface Tour
3. Course Overview

EPIDEMIOLOGY
4. Objectives
5. Definition of MDD
6. Epidemiology of MDD
7. Risk Factors for Depression
8. Progress Check

PATHOPHYSIOLOGY: MONOAMINES
9. Objectives
10. Neurotransmission in the CNS
11. Monoamine Neurotransmitters
12. The Monoamine Hypothesis
13. Progress Check

PATHOPHYSIOLOGY: THE HPA AXIS
14. Objectives
15. Implicated Brain Regions
16. Stress and the HPA Axis
17. Progress Check

CONCLUSION
18. Summary

COURSE OBJECTIVES

Students completing this course should be able to:

Provide a definition for major depressive disorder (MDD) and explain the differences between unipolar and bipolar disorders
Discuss the differing prevalence of MDD in various populations
Review how certain risk factors influence susceptibility to MDD
Explain the main steps of synaptic neurotransmission in the CNS
Discuss the monoamine theory of depression
Identify specific brain regions and the associated neurotransmitter-releasing neurons that are involved in MDD
Describe the typical reaction of the HPA axis to stress
Explain how HPA axis dysregulation contributes to the pathogenesis of MDD

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