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Antibiotic Therapy: Resistance and Use
Description: The advanced bioinformatics course is designed to explain the algorithms, tools, databases, and applications of bioinformatics. In particular, complex applications applied to drug discovery are described.
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COURSE OUTLINE
INTRODUCTION
1. Course Information
2. Interface Tour
3. Course Overview
BACTERIAL RESISTANCE
4. Objectives
5. Intrinsic and Acquired Resistance
6. Mutations
7. Acquisition of Plasmids
8. Mechanisms of Resistance
9. Resistance to Penicillin
10. Resistance to Other Drug Classes
11. Progress Check
HOST FACTORS IN ANTIBIOTIC SELECTION
12. Objectives
13. Immune System Status
14. Drug Action and Infection Site Factors
15. Age
16. Pregnancy and Lactation
17. Renal and Hepatic Function
18. Other Host Factors
19. Progress Check
PHARMACOLOGY
20. Objectives
21. Disk Diffusion Testing
22. Minimal Inhibitory Concentration (MIC)
23. Minimal Bactericidal Concentration (MBC)
24. PK/PD and MIC
25. PK/PD Effects on Efficacy
26. Combination Therapy Activity and Spectrum
27. Combination Therapy Effects and Agents
28. Drug Interactions
29. Progress Check
PROPHYLAXIS AND ICU CARE
30. Objectives
31. General Principles of Antibiotic Prophylaxis
32. Targeted Prophylaxis
33. Prophylaxis Against Secondary Infections
34. Prophylaxis in Surgical Procedures
35. Infection in the ICU
36. Antibiotics in Critical Care
37. Progress Check
CONCLUSION
38. Summary
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COURSE OBJECTIVES
Students completing this course should be able to:
- Describe intrinsic causes of bacterial resistance
- Explain how bacteria acquire resistance
- List three mechanisms of bacterial resistance
- Describe the effect of a patient's immune system on antibiotic selection
- List the two infection site factors involved in selecting an antibiotic
- Explain how age and genetic factors influence antibiotic choice
- Explain renal and hepatic function and its involvement in selecting an antibiotic
- List other host factors that are used to choose an antibiotic
- List three common tests for assessing bacterial sensitivity
- Explain how PK/PD parameters are used to determine drug dosage
- Describe three common antibiotic combinations and the rationale for their use
- Describe common antibiotic-drug interactions
- List two prophylactic uses of antibiotics
- Describe factors in selecting antibiotics for prophylaxis
- List three common ICU infections
- Describe the factors used to select antibiotics for intensive care units
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SeerPharma has partnered with GeneEd to now distribute courses in Major Therapeutic Areas, Clinical Research, and Biotechnology & Genetics.
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